The 2021 Lexus RX delivers 21 to 23 MPG combined across 4 powertrain combinations. If fuel cost matters to you, pay attention to engine and drivetrain. The spread is significant.

By Trim

RX 350 - Automatic (S8)

23mpg

3.5L 6-cyl · Front-Wheel Drive

20 city27 hwy~$1,900/yr5/10 Average

RX 350 AWD - Automatic (S8)

22mpg

3.5L 6-cyl · All-Wheel Drive

19 city26 hwy~$2,000/yr4/10 Average

RX 350 L - Automatic (S8)

22mpg

3.5L 6-cyl · Front-Wheel Drive

19 city26 hwy~$2,000/yr4/10 Average

RX 350 L AWD - Automatic (S8)

21mpg

3.5L 6-cyl · All-Wheel Drive

18 city25 hwy~$2,100/yr4/10 Average

Source: U.S. Environmental Protection Agency (EPA)

Where to Find 2021 Lexus RX

30States

35%in top 3

Texas has the most inventory at 13%, with options spread across 30 states. Willing to ship? Your selection opens up significantly.

TXTexas

1,31513%

FLFlorida

1,12811%

CACalifornia

1,05910%

DCWashington DC

6687%

NYNew York

5425%

MDMaryland

5005%

GAGeorgia

4284%

NJNew Jersey

4064%

NCNorth Carolina

3864%

PAPennsylvania

3584%

ILIllinois

3223%

AZArizona

2813%

COColorado

2272%

MOMissouri

2262%

DE201

AL151

WA146

TN140

NH137

CT137

MN126

NV122

UT115

MA107

WI96

MI94

OK84

OH72

LA61

SC58

Geographic distribution reflects all active listings for this model, not just 2021.

2021 Lexus RX: Questions Buyers Ask

Pricing, reliability, and ownership answers

Is the 2021 Lexus RX a good car to buy?

The 2021 Lexus RX has its strengths and its watch-outs. Check the safety section for recall details and the pricing data to see if the numbers work for you.

What's the gas mileage of the 2021 Lexus RX?

Depending on configuration, the 2021 Lexus RX delivers 21–23 MPG combined. Choose wisely. The full comparison shows how engine choice affects your wallet.

How does the 2021 compare to other Lexus RX years?

Each Lexus RX model year has different pricing, recall counts, and owner satisfaction patterns. Compare all available years on the Lexus RX overview page.